Amphotericin B (Injection)

Introduction

Amphotericin B (am-foe-TER-i-sin B)

Treats infections caused by a fungus. Belongs to a class of drugs called antifungals.

Brand Name(s)

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Make sure your doctor knows if you are taking a diuretic (water pills), digoxin (Lanoxin®), a corticosteroid (such as prednisone or cortisone), other antifungal medicine (such as Ancobon®, Nizoral®, or Monistat®) or any antibiotic before you take this medicine.

When This Medicine Should Not Be Used

How to Use This Medicine

Injectable

• Your doctor will prescribe your exact dose and tell you how often it should be given. Keep all medicine out of the reach of children.
• An IV infusion is medicine that is put directly into your body through one of your veins.
• This medicine should be given by a person trained to give an IV, such as a nurse. Sometimes you, a family member, or friend can be taught to give your medicine.
• Check the bag to make sure there are no leaks. Also make sure the solution is clear.

If a dose is missed:

• This medicine needs to be given on a regular schedule. Take the missed dose as soon as you remember.
• If you miss more than one dose, call your doctor for instructions.

How to Store and Dispose of This Medicine

• Store in a refrigerator. Do not freeze. Take it out of the refrigerator an hour before the time for your next dose and allow it to warm to room temperature in a clean, dry place.
• If you see particles in the solution, You should not use it.
• If you have your treatments at home, you should be given a special container for the used needles. Keep it where children or pets cannot reach it.

Warnings While Using This Medicine

• If you are pregnant or breastfeeding, talk to your doctor before taking this medicine.
• Make sure your doctor knows if you have kidney disease.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

• Severe nausea and vomiting
• Shaking and chills
• Numbness or tingling in the hands or feet
• Swelling of the face, lips, or tongue
• Trouble breathing
• Swelling, pain, or redness near where the IV needle is given
• Water retention (swelling of the ankles and feet)
• Urinating less than 1 cup in a day
• Severe weakness, muscle cramps

If you notice these less serious side effects, talk with your doctor:

• Mild diarrhea
• Mild nausea or upset stomach

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088