Busulfan (Injection)

Introduction

Busulfan (bue-SUL-fan)

Treats certain kinds of leukemia. Also given to prepare the body for a stem cell transplant.

Brand Name(s)

Busulfex

When This Medicine Should Not Be Used

How to Use This Medicine

Injectable

• This medicine, like all medicines used to treat cancer, is very strong. Make sure you understand why you are getting it and what the risks and benefits of treatment are. It is important for you to work closely with your doctor.
• You will receive this medicine while you are in a hospital or chemotherapy treatment center.
• Your medicine will be given through a tube put into your chest. This is called a central venous catheter.
• Before receiving busulfan, you will be given medicines to help prevent vomiting and other side effects.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Make sure your doctor knows about all other medicines you are taking or have taken within the week before you receive busulfan.

Warnings While Using This Medicine

• If you are pregnant or breastfeeding, talk to your doctor before receiving this medicine.
• Before receiving busulfan, let your doctor know if you have ever had seizures or a head injury.
• Let your doctor know if you have ever received radiation treatments, other stem cell transplants, or other types of chemotherapy.
• Your doctor will need to check your blood at regular times during your treatment.
• Busulfan lowers your body's ability to fight infection. While you are receiving this medicine, avoid exposure to people with colds or infections.
• This medicine causes nausea and vomiting in most people, even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects.
• Receiving busulfan may increase your risk of developing other types of cancer or a recurrence of leukemia. Talk to your doctor about this risk.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

• Back pain
• Diarrhea
• Fever, chills, or sore throat
• Sores or ulcers on the lips or in the mouth

If you notice these less serious side effects, talk with your doctor:

• Anxious feeling
• Change in menstrual periods
• Headache
• Loss of appetite
• Skin rash
• Stomach pain
• Trouble sleeping

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088