Dasatinib (By mouth)

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you use medicine to treat bacterial infections (such as clarithromycin, erythromycin, telithromycin, Biaxin®, E-Mycin®, or Ketek®), fungus infections (such as itraconazole, ketoconazole, voriconazole, Nizoral®, or Sporanox®), HIV or AIDS (such as atazanavir, indinavir, nelfinavir, ritonavir, saquinavir, Crixivan®, Invirase®, Norvir®, Reyataz®, or Viracept®), or a blood thinner such as warfarin (Coumadin®) or aspirin.
  • Tell your doctor if you also use alfentanil (Alfenta®), astemizole (Hismanal®), carbamazepine (Tegretol®), cisapride (Propulsid®), cyclosporine (Gengraf®, Neoral®, Sandimmune®), dexamethasone (Decadron®), doxorubicin (Adriamycin®), fentanyl (Duragesic®), nefazodone (Remeron®, Serzone®), phenobarbital (Luminal®), phenytoin (Dilantin®), pimozide (Orap®), quinidine (Cardioquin®), rifabutin (Mycobutin®), rifampicin (Rifadin®, Rimactane®), simvastatin (Zocor®), sirolimus (Rapamune®), tacrolimus (Prograf®), terfenadine (Seldane®), ergotamine medicines (such as dihydroergotamine, ergotamine, Cafergot®, D.H.E. 45®, Ergomar®, Migranal®, or Wigraine®), or St. John's wort.
  • If you use antacids (such as Maalox®, Rolaids®, or Tums®), take it at least 2 hours before or 2 hours after you take dasatinib. Tell your doctor if you also use heartburn medications such as cimetidine (Tagamet®), esomeprazole (Nexium®), famotidine (Pepcid®), lansoprazole (Prevacid®), omeprazole (Prilosec®), pantoprazole (Protonix®), rabeprazole (Aciphex®), or ranitidine (Zantac®).
  • Do not eat grapefruit or drink grapefruit juice while you are using this medicine.

Warnings While Using This Medicine

  • Tell your doctor right away if you think you have become pregnant while using the medicine. You can harm your unborn baby if you use this medicine while you are pregnant. Use an effective form of birth control so you do not get pregnant.
  • Make sure your doctor knows if you are breastfeeding or if you have a blood problem such as anemia, bleeding problems, heart disease, heart rhythm problems, low potassium or magnesium levels in your blood, fluid problems (edema), or problems when you take lactose.
  • This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Avoid people who are ill, and wash your hands often. Brush and floss your teeth gently, do not play rough sports, and be careful with sharp objects.
  • This medicine can cause changes in your heart rhythm. It may change the way your heart beats and cause you to faint or have serious side effects. Tell your doctor right away if you have any symptoms of heart rhythm problems, such as fast, pounding, or uneven heartbeats.
  • Check with your doctor right away if you have the following symptoms while taking this medicine: chest discomfort or pain; decrease in how much you urinate; fast, irregular, or pounding heartbeat; shortness of breath; swelling of the feet or lower legs; troubled breathing; or unusual tiredness or weakness. These could be symptoms of a serious heart problem.
  • This medicine may cause headache, muscle or joint pain, skin rash, or unusual tiredness or weakness. Check with your doctor if these symptoms continue or become worse.
  • Dasatinib may cause fluid retention. Check with your doctor right away if you have a decrease in how much you urinate; noisy or rattling breathing; shortness of breath; swelling of the fingers, hands, feet, or lower legs; troubled breathing at rest; or weight gain.
  • This medicine may increase your risk of pulmonary arterial hypertension (high blood pressure in the vessels of your lungs). This may occur at anytime during your treatment with this medicine. Check with your doctor right away if you have shortness of breath, troubled breathing, tiredness, or swelling all over your body (fluid retention).
  • Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Change in how much or how often you urinate
  • Chest pain
  • Fast, pounding, or uneven heartbeat
  • Fever, chills, cough, runny or stuffy nose, sore throat, and body aches
  • Lightheadedness, dizziness, drowsiness, or fainting
  • Rapid weight gain
  • Red or black stools
  • Severe stomach pain
  • Shortness of breath, cold sweats, and bluish-colored skin
  • Swelling in your hands, ankles, or feet
  • Unusual bleeding, bruising, or weakness
  • Vomiting of blood or material that looks like coffee grounds

If you notice these less serious side effects, talk with your doctor:

  • Diarrhea, nausea, vomiting, or stomach pain
  • Mild headache
  • Muscle or joint pain or stiffness
  • Skin rash
  • Tiredness

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Introduction

Dasatinib (da-SA-ti-nib)

Treats different kinds of leukemia. This is an antineoplastic (cancer) medicine.

Brand Name(s)

Sprycel

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to dasatinib or if you are pregnant or plan to become pregnant.

How to Use This Medicine

Tablet

  • Medicines used to treat cancer are very strong and can have many side effects. Before receiving this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment.
  • Take your medicine as directed. Your dose may need to be changed several times to find what works best for you.
  • You may take this medicine with or without food.
  • Swallow the tablet whole. Do not crush, break, or chew it.
  • Take this medicine for as long as your doctor has told you to. Do not change your dose or stop taking this medicine without first talking with your doctor.
  • Dasatinib tablets should be handled with care. People (especially pregnant women) who do not take this medicine should not handle crushed or broken tablets. If tablets are broken or crushed, wear disposable chemotherapy gloves so that you do not come into contact with the medicine.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any leftover medicine after you have finished your treatment. You will also need to throw away old medicine after the expiration date has passed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.
Review Date: March 4, 2014
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.
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