Dutasteride/tamsulosin (By mouth)

Introduction

Dutasteride (doo-TAS-ter-ide), Tamsulosin Hydrochloride (tam-SOO-loe-sin hye-droe-KLOR-ide)

Treats problems with urination caused by an enlarged prostate (benign prostatic hyperplasia or BPH). This medicine is a combination of a 5-alpha-reductase inhibitor and an alpha-blocker.

Brand Name(s)

Jalyn

There may be other brand names for this medicine.

When This Medicine Should Not Be Used

You should not use this medicine if you have had an allergic reaction to dutasteride, tamsulosin, or similar medicines such as finasteride, Propecia®, or Proscar®. Women and children should not use this medicine.

How to Use This Medicine

Capsule

  • Take your medicine as directed.
  • It is best to take the capsule approximately 30 minutes after the same meal each day. Swallow the capsule whole. Do not chew or open it.
  • Read and follow the patient instructions that come with this medicine. Talk to your doctor or pharmacist if you have any questions.

If a dose is missed:

  • Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

  • Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
  • Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
  • Keep all medicine out of the reach of children. Never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

  • Make sure your doctor knows if you are also using ciprofloxacin (Cipro®), ketoconazole (Nizoral®), ritonavir (Kaletra®, Norvir®), or other alpha blockers such as doxazosin (Cardura®), prazosin (Minipress®, Minizide®), or terazosin (Hytrin®).
  • Tell your doctor if you are using cimetidine (Tagamet®), erythromycin (Ery-Tab®), paroxetine (Paxil®), terbinafine (Lamisil®), troleandomycin (Tao®), medicine for erectile dysfunction (such as sildenafil, tadalafil, vardenafil, Cialis®, Levitra®, or Viagra®), or a blood thinner (such as warfarin, Coumadin®).

Warnings While Using This Medicine

  • Women who are pregnant or may become pregnant should avoid touching or handling this medicine. This medicine can get into the body through the skin and can harm an unborn male baby. If any of this medicine gets on the skin of a pregnant woman, wash the area immediately with soap and water, especially if the capsule is broken.
  • Make sure your doctor knows if you have liver disease, low blood pressure, prostate cancer, or an allergy to sulfa drugs such as sulfamethoxazole, sulfasalazine, sulfasoxazole, Azulfidine®, Bactrim®, or Septra®.
  • This medicine may make you dizzy. Avoid driving, using machines, or doing anything else that could be dangerous if you are dizzy or are not alert.
  • Dizziness, lightheadedness, or fainting may occur after you take this medicine, especially when you get up suddenly from a lying or sitting position. Getting up slowly may help. If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to keep the dizziness from returning.
  • This medicine may affect the results of the prostate specific antigen (PSA) test, which may be used to detect prostate cancer. Make sure you tell all of your doctors that you are using this medicine.
  • This medicine will not prevent prostate cancer but may increase your risk of developing high-grade prostate cancer. Tell your doctor if you have concerns about this risk.
  • Do not donate blood until 6 months have passed since your last dose. This medicine can remain in your blood for a long time and be passed on to a pregnant woman who receives a blood transfusion.
  • This medicine does not usually affect normal sexual abilities in most men. You may notice that you ejaculate less fluid when you have sex.
  • If you plan to have cataract surgery, tell your eye doctor (ophthalmologist) that you are taking this medicine or that you used this medicine in the previous 9 months. A serious eye problem called Intraoperative Floppy Iris Syndrome (IFIS) has occurred in some patients who were taking this medicine or who had recently taken this medicine when they had cataract surgery.
  • You should seek medical attention right away if you experience a prolonged erection while using this medicine. This is an extremely rare unwanted effect that must be treated right away to prevent permanent erectile damage (impotence).
  • Your doctor will check your progress and the effects of this medicine at regular visits. Keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

  • Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
  • Chest pain.
  • Feeling of constant movement of self or surroundings.
  • Fever, chills, cough, sore throat, and body aches.
  • Lightheadedness, dizziness, or fainting.
  • Painful, prolonged erection of the penis not caused by sexual arousal.

If you notice these less serious side effects, talk with your doctor:

  • Back pain.
  • Decrease or change in your sexual desire.
  • Diarrhea, nausea, or vomiting.
  • Enlarged and painful breasts.
  • Lack or loss of strength.
  • Problems with ejaculation.
  • Runny or stuffy nose.
  • Sleepiness or unusual drowsiness.
  • Tiredness or weakness.
  • Trouble sleeping.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Review Date: March 4, 2014
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites.
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