Lubiprostone (By mouth)

Introduction

Lubiprostone (loo-bi-PROST-one)

Treats certain types of long-term constipation by helping you have a bowel movement. Also treats irritable bowel syndrome (IBS) in women who have constipation as the main symptom.

Brand Name(s)

Amitiza

When This Medicine Should Not Be Used

How to Use This Medicine

Capsule, Liquid Filled Capsule

• Your doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
• It is best to take this medicine with food or milk.
• Swallow the capsule whole. Do not crush, break, or chew it.
• Take each dose with at least 8 ounces (1 cup) of water. Drink at least 6 to 8 full glasses of liquid every day to help soften your stools (bowel movements).

If a dose is missed:

• If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

How to Store and Dispose of This Medicine

• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
• Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
• Keep all medicine away from children and never share your medicine with anyone.

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

Warnings While Using This Medicine

• If you are a woman who can get pregnant, your doctor may want you to have a negative pregnancy test before you will be allowed to take this medicine. Also, use an effective form of birth control to keep from getting pregnant. If you miss a period while you are using this medicine, tell your doctor right away.
• Make sure your doctor knows if you are breastfeeding, or if you have liver disease, stomach pain, nausea, vomiting, severe diarrhea, or a sudden change in bowel habits.
• This medicine may cause difficulty with breathing, nausea, or severe diarrhea. If your symptoms and condition do not improve within a few days, or if they become worse, check with your doctor.
• Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Chest pain or shortness of breath.
• Difficulty with breathing.
• Nausea, vomiting, severe diarrhea, loose or watery stools, or stomach pain or swelling.
• Swelling in your hands, ankles, and feet.

If you notice these less serious side effects, talk with your doctor:

• Dizziness or headache.
• Dry mouth.
• Passing gas or upset stomach.
• Tiredness.
• Warmth or redness in your face, neck, arms, or upper chest.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088