Trandolapril (By mouth)

How to Store and Dispose of This Medicine

• Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
• Ask your pharmacist, doctor, or health caregiver about the best way to dispose of any outdated medicine or medicine no longer needed.
• Keep all medicine away from children and never share your medicine with anyone.

Warnings While Using This Medicine

• Using this medicine while you are pregnant (especially in your second or third trimester) can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.
• Make sure your doctor knows if you have kidney problems, liver disease, heart or blood vessel disease, congestive heart failure, low blood pressure, low blood volume, or mineral imbalance (such as high potassium or low sodium in the blood). Tell your doctor if you have diabetes, lupus, an autoimmune disorder (such as collagen vascular disease or scleroderma), or a history of airway surgery.
• This medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life.
• This medicine may cause serious types of allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, or mouth while you are using this medicine.
• Tell your doctor about any allergic reaction you have had to any drug, especially if the reaction caused you to have swelling in your face, lips, tongue, or throat.
• Stop using this medicine and call your doctor right away if you have severe stomach pain (with or without nausea or vomiting). This could be a symptom of a condition called intestinal angioedema.
• This medicine might sometimes lower your blood pressure too much. If your blood pressure gets too low, you will feel dizzy or lightheaded, especially when you stand up. This is more likely to happen when you first start using the medicine or if your body loses too much water or salt. Some things that could cause this are: if you use a diuretic or "water pill" for a long time, eat a low-salt diet, are on kidney dialysis, have diarrhea or vomiting, do not drink enough water, or sweat heavily. If you faint, stop using this medicine until you have talked to your doctor.
• Check with your doctor if you notice any signs of fever, chills, or sore throat. These could be symptoms of an infection resulting from low white blood cell counts.
• Stop using this medicine and check with your doctor right away if you have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem.
• Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.
• Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain medical tests.
• This medicine may make you dizzy or drowsy. Avoid driving, using machines, or doing anything else that could be dangerous if you are not alert.
• Your doctor will need to check your progress at regular visits while you are using this medicine. Be sure to keep all appointments. Blood and urine tests may be needed to check for unwanted effects.
• Black patients may be less sensitive to the blood pressure-lowering effects of this medicine. In addition, the risk of a serious allergic reaction involving swelling of the face, mouth, hands, or feet may be increased.
• If you stop using this medicine, your blood pressure may go up. High blood pressure usually has no symptoms. Even if you feel well, do not stop using the medicine without asking your doctor.

Possible Side Effects While Using This Medicine

Call your doctor right away if you notice any of these side effects:

• Allergic reaction: Itching or hives, swelling in your face or hands, swelling or tingling in your mouth or throat, chest tightness, trouble breathing
• Change in how much or how often you urinate, or problems urinating
• Chest pain (may be related to your disease and not a side effect)
• Confusion, body weakness, or numbness or tingling in hands, feet, or lips
• Dark-colored urine or pale stools
• Dry mouth, increased thirst, or muscle cramps
• Fast, slow, pounding, or uneven heartbeat
• Fever, chills, sore throat, and body aches
• Lightheadedness, dizziness, or fainting
• Nausea, vomiting, loss of appetite, or stomach pain
• Severe stomach pain (with or without nausea)
• Shortness of breath, cold sweat, or bluish-colored skin
• Swelling in your hands, ankles, or feet
• Yellowing of your skin or the whites of your eyes

If you notice these less serious side effects, talk with your doctor:

• Change in sense of taste
• Dry cough
• Headache
• Mild nausea, vomiting, diarrhea, or upset stomach
• Mild skin rash
• Muscle or joint pain
• Weakness

Brand Name(s)

Mavik

How to Use This Medicine

Tablet

• Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.
• You may take this medicine with or without food.
• Carefully follow your doctor's instructions about any special diet. Be sure to drink plenty of fluids if you exercise, sweat more than usual, or have diarrhea or vomiting. Check with your doctor right away if you continue to experience diarrhea or vomiting.

If a dose is missed:

• If you miss a dose or forget to use your medicine, use it as soon as you can. If it is almost time for your next dose, wait until then to use the medicine and skip the missed dose. Do not use extra medicine to make up for a missed dose.

If you notice other side effects that you think are caused by this medicine, tell your doctor

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088

Introduction

Trandolapril (tran-DOE-la-pril)

Used alone or together with other medicines to treat high blood pressure (hypertension) and heart failure. Also used in the first few days after a heart attack. Helps to reduce the risk of death by making the heart more stable after the attack. This medicine is an angiotensin-converting enzyme (ACE) inhibitor.

When This Medicine Should Not Be Used

Drugs and Foods to Avoid

Ask your doctor or pharmacist before using any other medicine, including over-the-counter medicines, vitamins, and herbal products.

• Make sure your doctor knows if you are also using lithium (Eskalith®, Lithobid®), gold injections (such as sodium aurothiomalate), or diuretic or "water pills" (such as amiloride, chlorthalidone, spironolactone, triamterene, Aldactazide®, Aldactone®, Combipres®, Dyazide®, Dyrenium®, Lasix®, Maxzide®, Midamor®, Moduretic®, or Tenoretic®).
• Tell your doctor if you are also using a pain or arthritis medicine, sometimes called "NSAIDs", such as aspirin, celecoxib, diclofenac, ibuprofen, naproxen, piroxicam, rofecoxib, valdecoxib, Advil®, Aleve®, Bextra®, Celebrex®, Feldene®, Motrin®, Vioxx®, or Voltaren®.
• Do not use medicines, supplements, or salt substitutes that contain potassium without checking first with your doctor.