An ACTH test measures ACTH, a hormone released from the anterior pituitary gland in the brain.
Serum adrenocorticotropic hormone; Adrenocorticotropic hormone; Highly-sensitive ACTH
How the test is performed
A blood sample is needed. For information on how this is done, see: Venipuncture
ACTH levels change with the body's natural 24-hour cycle of processes (circadian rhythms). This test is most accurate if it is performed early in the morning.
How to prepare for the test
The health care provider may advise you to stop taking steroid drugs. You may need to be at the laboratory or office where the blood is being drawn by or before 8 a.m.
How the test will feel
When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.
Why the test is performed
This test can help find the causes of hormone problems.
The main function of ACTH is to regulate the steroid hormone cortisol, which is released by the adrenal cortex.
Normal values: 9 - 52 pg/mL
Note: pg/mL = picograms per milliliter
The examples above are common measurements for results for these tests. Some laboratories use different measurements or may test different specimens. Normal value ranges may vary slightly among different labs. Talk to your doctor about the meaning of your specific test results.
What abnormal results mean
Higher-than-normal levels of ACTH may be present with:
- Addison's disease, when the adrenal glands do not produce enough cortisol
- Congenital adrenal hyperplasia
- When the pituitary makes too much of the hormone ACTH (called Cushing's disease), which may be caused by excess growth of the pituitary gland, or tumors of the pituitary gland or elsewhere in the body (such as the pancreas, lung, and thyroid)
Lower-than-normal levels of ACTH may be seen with:
- Pituitary gland that is not producing enough hormones, such as ACTH
- Tumor of the adrenal gland that produces too much cortisol
- Tumor elsewhere in the body that produces cortisol
Other conditions under which the test may be performed:
What the risks are
Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.
Other risks associated with having blood drawn are slight but may include:
- Excessive bleeding
- Fainting or feeling lightheaded
- Hematoma (blood accumulating under the skin)
- Infection (a slight risk any time the skin is broken)
Special handling of the blood sample is required.
Stewart PM, Krone NP. The adrenal cortex. In: Kronenberg HM, Melmed S, Polonsky KS, Larsen PR, eds. Williams Textbook of Endocrinology. 12th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap 15.
Melmed S, Kleinberg D. Pituitary masses and tumors. In: Kronenberg HM, Melmed S, Polonsky KS, Larsen PR, eds. Williams Textbook of Endocrinology. 12th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap 9.
The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed medical professional should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. ©1997-2014 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.
Sign Up for Free Newsletters
Ask Your Doctor the RIGHT Questions!
the most from your doctor visit.
Emailed right to you!
The Ask Your Doctor email series
may contain sponsored content.
18+, US residents only please.
Explore Original Articles About...
Get the MOST from QualityHealth
- Top Searches
- 1. Arthritis Management: Nature Heals
- 2. 5 Digestive To-Dos
- 3. Men: Should You Shave It or Leave It?
- 4. Today's Top Fitness Trends
- 5. Sugar and Osteoarthritis : The Link
- 6. Can't Afford Your Hospital Bills?
- 7. Stay Energized All Day Long
- 8. Phobias: Who Has Them and Why?
- 9. What If Your EpiPen Fails?
- 10. 5 Costly Medical Billing Mistakes
- 1. Hotter Temperatures Linked To Kidney Stones
- 2. Summer Bug Bites: What to Look For
- 3. Skin Health Advice with Dr. Kenneth Beer
- 4. Summer Safety Tips That Every Parent Needs To Know
- 5. Sugar and Your Immunity System
- 6. Do Weight Loss Supplements Work?
- 7. 5 Super Foods for Spring
- 8. The Hazards of Reusable Bags
- 9. How to Avoid Ingrown Hairs
- 10. Health Tip: Constantly Change Shoes
- 1. 4 Common Treatments for Epilepsy
- 2. What Does a Urogynecologist Do?
- 3. GERD Without Heartburn? It's Possible
- 4. Graston Technique: Can It Work on You?
- 5. Music Therapy Can Help Autism
- 6. 8 Ways to Fight MS-Related Fatigue
- 7. Can You Still Bleed After Menopause?
- 8. Be Your Own Health Care Advocate
- 9. Why Is Syphillis on the Rise?
- 10. Ideal Weight vs. Happy Weight
The material on the QualityHealth Web site is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a physician or other qualified health provider. See additional information.