Factor V deficiency
Factor V deficiency is an inherited condition that affects the ability of the blood to clot.
Parahemophilia; Owren's disease
Causes, incidence, and risk factors
Normal blood coagulation is a complex process involving as many as 20 different proteins in blood plasma, which are known as blood coagulation factors. A series of complex chemical reactions using these factors takes place very rapidly to form a protein called fibrin, which stops bleeding.
Factor V deficiency is caused by a lack of the plasma protein Factor V. When certain coagulation factors are low or missing, the chain reaction does not take place normally. Factor V deficiency is rare, and can be caused by inheriting a defective Factor V gene or by acquiring an antibody that interferes with normal Factor V function.
You can acquire an inhibitor of Factor V:
- After giving birth
- After being treated with a certain type of fibrin glue
- After surgery
- With autoimmune diseases and certain cancers
Sometimes the cause is unknown.
Excessive bleeding with menstrual periods and after delivery often occurs. Men and women are affected equally. About 1 person per 1 million has the disorder.
Signs and tests
You should receive fresh blood plasma or fresh frozen plasma infusions during a bleeding episode or after surgery. These treatments will correct the deficiency temporarily.
You can often help the stress of illness by joining a support group where members share common experiences and problems.
The outlook is good with diagnosis and proper treatment.
Severe bleeding (hemorrhage) could occur.
Calling your health care provider
Go to the emergency room or call the local emergency number (such as 911) if you have an unexplained or prolonged loss of blood.
This is an inherited disorder; there is no known prevention.
Asselta R, Tenchini ML, Duga S. Inherited defects of coagulation Factor V: the hemorrhagic side. J Thromb Haemost. 2006 Jan;4(1):26-34.
Kessler CM. Hemorrhagic disorders: coagulation factor deficiencies. In: Goldman L, Ausiello D, eds. Cecil Medicine. 23rd ed. Philadelphia, Pa: Saunders Elsevier; 2007:chap 180.
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