Baby research challenged in new report
NEW YORK (Reuters Health) - Tests of medical treatments in babies vary markedly in quality, at least as judged by the reports that make it into scientific journals, researchers say.
That's a problem, they assert, because trials that don't follow rigorous scientific standards are more prone to bias that makes the results unreliable.
Ultimately, those results trickle down into patient care, dictating what drugs and devices doctors use to help ailing children, said Dr. Sara B. DeMauro, of The Children's Hospital of Philadelphia, who worked on the findings.
"There is always the possibility that the authors did do something and then forgot to report it, but that's less likely," she told Reuters Health.
DeMauro and her colleagues rated 179 randomized controlled trials -- the "gold standard" study design -- published in six prestigious medical journals, including three that specialized in pediatric medicine and three general medical publications.
The researchers used 11 criteria from the Consolidated Standards of Reporting Trials (CONSORT) checklist, which is in wide use in the medical community.
Half of the reports fulfilled nine or fewer criteria, with less than a quarter meeting all of them.
In particular, there were problems with how participants were assigned to the active treatment or to a dummy or a standard treatment. And as many as 21 percent of the articles didn't state what the trial aimed to test, the so-called primary outcome.
"Without a primary outcome, everything else is superfluous," said DeMauro. "So when some authors are not even giving you a clear primary outcome, you have to question the whole study."
The shortcomings were particularly clear at pediatric journals, such as Pediatrics, in which the new findings themselves are published. On the other hand, general medical journals such as the Journal of the American Medical Association and the New England Journal of Medicine did much better.
The new data add to mounting evidence of subpar reporting practices in the medical community, which in turn can make it hard to create treatment guidelines.
Earlier this year, for instance, German doctors looking to establish guidelines for how to treat bipolar disorder said they had to give up because the trials in medical journals were so skimpily reported that they didn't know what results they could trust. (See Reuters Health story of Feb 9, 2011 at http://reut.rs/i0HART)
According to DeMauro, it's time that all medical journals begin to require higher standards in the reports they publish. While most do recommend following the CONSORT guidelines, "it is not being enforced," she said.
"When reporting a clinical trial, those criteria should be followed very strictly," she added.
SOURCE: http://bit.ly/nLwCWR Pediatrics, online August 22, 2011.
Sign Up for Free Newsletters
Ask Your Doctor the RIGHT Questions!
the most from your doctor visit.
Emailed right to you!
The Ask Your Doctor email series
may contain sponsored content.
18+, US residents only please.
Get the MOST from QualityHealth
- Top Searches
- 1. Arthritis Management: Nature Heals
- 2. 5 Digestive To-Dos
- 3. Men: Should You Shave It or Leave It?
- 4. Today's Top Fitness Trends
- 5. Sugar and Osteoarthritis : The Link
- 6. Can't Afford Your Hospital Bills?
- 7. Stay Energized All Day Long
- 8. Phobias: Who Has Them and Why?
- 9. What If Your EpiPen Fails?
- 10. 5 Costly Medical Billing Mistakes
- 1. Ice Falls Can Cause Serious Injuries
- 2. Can Inactivity Act Like a Disease?
- 3. Kale Snack Recipe for Diabetics
- 4. How Running Affects Arthritis
- 5. Sugar and Your Immunity System
- 6. Do Weight Loss Supplements Work?
- 7. 5 Super Foods for Spring
- 8. The Hazards of Reusable Bags
- 9. How to Avoid Ingrown Hairs
- 10. Health Tip: Constantly Change Shoes
- 1. 4 Common Treatments for Epilepsy
- 2. What Does a Urogynecologist Do?
- 3. GERD Without Heartburn? It's Possible
- 4. Graston Technique: Can It Work on You?
- 5. Music Therapy Can Help Autism
- 6. 8 Ways to Fight MS-Related Fatigue
- 7. Can You Still Bleed After Menopause?
- 8. Be Your Own Health Care Advocate
- 9. Why Is Syphillis on the Rise?
- 10. Ideal Weight vs. Happy Weight
The material on the QualityHealth Web site is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a physician or other qualified health provider. See additional information.