Gene could explain why asthma treatments fail some
CHICAGO (Reuters) - Genetic differences could explain why some 40 percent of people with asthma do not respond to inhaled steroids used to achieve long-term asthma control.
U.S. researchers have found that asthma patients who inherited two copies of a specific gene variant were far less likely to respond to steroid inhalers than people with two copies of the more common version of the gene.
"This finding helps to explain the genetic basis for the long-standing observation that some people do not respond well to what is a common asthma treatment," said Dr. Susan Shurin, acting director of the National Heart Lung and Blood Institute, which sponsored the study released online on Monday in the New England Journal of Medicine.
The findings point the way to more personalized treatments for asthma, an inflammatory disease that affects more than 22 million Americans and some 300 million people worldwide.
Inhaled steroids work by reducing swelling of the airways.
"The study illustrates the importance of research examining the relationship between genetic makeup and response to therapy for asthma, and underscores the need for personalized treatment for those who have it," said Shurin, whose agency is part of the National Institutes of Health.
For the study, researchers from Brigham and Women's Hospital and Harvard Medical School - both in Boston - analyzed the genetic information from more than 1,000 people enrolled in clinical trials evaluating different asthma treatments.
The researchers used a family based model in which they studied the genetic makeup of children with asthma and their parents to identify genes that might play a role in response to inhaled steroids, such as AstraZeneca's budesonide sold under the Pulmicort brand and Glaxosmithkline's fluticasone or Flovent, a key ingredient in its Advair asthma treatment.
The team, led by Dr. Kelan Tantisira, found that people who inherited two copies of a genetic variant to the GLCCI1 gene were less likely to respond to treatment.
In the poor responders, treatment with an inhaler produced just one third of the level of lung improvement as that seen in people with two regular copies of the gene.
NEJM Editor-in-Chief Dr. Jeffrey Drazen said in an editorial the study brings researchers closer to being able to identify which patients are most likely to respond to treatment from inhaled steroids, which are used by millions of people.
But much work still needs to be done to understand how genetic differences affect asthma treatment, Drazen said.
"Although these research results are a step forward, they are not the end of the road," Drazen wrote.
He said clinical trials will need to be done to see if understanding a person's genetic response to drugs helps improve treatment results.
The findings were presented on Monday at the European Respiratory Society Congress in Amsterdam.
SOURCE: http://bit.ly/p3U87I New England Journal of Medicine, online September 26, 2011.
Sign Up for Free Newsletters
Ask Your Doctor the RIGHT Questions!
the most from your doctor visit.
Emailed right to you!
The Ask Your Doctor email series
may contain sponsored content.
18+, US residents only please.
Get the MOST from QualityHealth
- Top Searches
- 1. Arthritis Management: Nature Heals
- 2. 5 Digestive To-Dos
- 3. Men: Should You Shave It or Leave It?
- 4. Today's Top Fitness Trends
- 5. Sugar and Osteoarthritis : The Link
- 6. Can't Afford Your Hospital Bills?
- 7. Stay Energized All Day Long
- 8. Phobias: Who Has Them and Why?
- 9. What If Your EpiPen Fails?
- 10. 5 Costly Medical Billing Mistakes
- 1. Hotter Temperatures Linked To Kidney Stones
- 2. Summer Bug Bites: What to Look For
- 3. Skin Health Advice with Dr. Kenneth Beer
- 4. Summer Safety Tips That Every Parent Needs To Know
- 5. Sugar and Your Immunity System
- 6. Do Weight Loss Supplements Work?
- 7. 5 Super Foods for Spring
- 8. The Hazards of Reusable Bags
- 9. How to Avoid Ingrown Hairs
- 10. Health Tip: Constantly Change Shoes
- 1. 4 Common Treatments for Epilepsy
- 2. What Does a Urogynecologist Do?
- 3. GERD Without Heartburn? It's Possible
- 4. Graston Technique: Can It Work on You?
- 5. Music Therapy Can Help Autism
- 6. 8 Ways to Fight MS-Related Fatigue
- 7. Can You Still Bleed After Menopause?
- 8. Be Your Own Health Care Advocate
- 9. Why Is Syphillis on the Rise?
- 10. Ideal Weight vs. Happy Weight
The material on the QualityHealth Web site is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a physician or other qualified health provider. See additional information.